Tirzepatide works by mimicking glucagon-like peptide-1 in the body to regulate blood sugar and appetite, which does not directly disqualify plasma donation, but your specific dosing schedule, overall health status, and donation facility's protocols will determine your actual eligibility
However, during the 37 day gap between stopping semaglutide and starting tirzepatide, some temporary appetite return is normal
[1] According to the SmPC, semaglutide undergoes proteolytic degradation and beta-oxidation with metabolites excreted in urine and faeces
Most of these events were gastrointestinal-related and included constipation, vomiting, diarrhea and nausea, and were more pronounced during the initial phase of treatment, particularly during dose escalation, and settled over time, Moiz said